課程資訊
課程名稱
藥品動態學
Pharmacokinetics 
開課學期
106-1 
授課對象
醫學院  臨床藥學研究所  
授課教師
林君榮 
課號
PHARM7005 
課程識別碼
423 M0400 
班次
 
學分
2.0 
全/半年
半年 
必/選修
選修 
上課時間
星期三9,10(16:30~18:20) 
上課地點
水森415 
備註
藥學系所主開課程與余秀瑛、胡幼圃、何蘊芳合授
總人數上限:20人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/1061PHARM7005_ 
課程簡介影片
 
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課程概述

Advance Pharmacokinetics is a continued course for Biopharmaceutics and Pharmacokinetics. The major purpose of this course is to teach students how to solve pharmacokinetic or pharmacodynamic problems using mathematical approaches. Some of the information and concepts from mathematics and elementary pharmacokinetics will be reviewed or developed as needed, but the balance of prerequisite material will be the student’s responsibility. Readings and homework will be assigned, or may be suggested to improve the learning efficiency of students. 

課程目標
Several topics will be introduced and elaborated in this course: Compartment Models; Pharmacokinetic / Pharmacodynamic (PK/PD) models; Physiological models; Nonlinear Pharmacokinetics; Absorption kinetics; Noncompartmental analysis;
Population pharmacokinetics. 
課程要求
It is important to develop an independent ability to construct pharmacokinetic (PK) and/or pharmacodynamic (PD) models corresponding to situations encountered in research and clinical study.
 
預期每週課後學習時數
 
Office Hours
 
指定閱讀
待補 
參考書目
Gibaldi and Perrier, Pharmacokinetics, 1982
Wagner, Fundamental of clinical pharmacokinetics, 1975
Rowland and Tozer, Clinical pharmacokinetics, 1995
Guterman and Nitecki, Differential equations, 1992
In addition to the recommended texts above, readings from other books, review articles or the primary scientific literature may be assigned or recommended by each instructor. Some of the faculty may also provide handout notes as a guide or supplement to their lectures.
 
評量方式
(僅供參考)
   
課程進度
週次
日期
單元主題
第1週
9/13  Compartment Models and Laplace Transform 
第2週
9/20  PK/PD Modeling 
第3週
9/27  Interspecies Scaling and PBPK 
第4週
10/04  中秋節停課 
第5週
10/11  Introduction of Simcyp 
第6週
10/18  Brief introduction of R 
第7週
10/25  Application of R in Pharmacometrics 
第8週
11/01  Population Pharmacokinetics 
第9週
11/08  期中考 
第10週
11/15  校慶停課 
第11週
11/22  BA/BE and Application of LC/MS/MS in Pharmacokinetic Study and Drug Development 
第12週
11/29  Tissue Distribution and Protein Binding 
第13週
12/06  Effect of a Drug on Serum Bilirubin Level and Risk 
第14週
12/13  Elucidate Contradictory Clinical Reports on Metabolic Rate of a Drug 
第15週
12/20  Nonlinear Pharmacokinetics 
第16週
12/27  Noncompartmental Analysis 
第17週
1/03  Absorption kinetics 
第18週
1/10  期末考